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Article

Global distribution of prophylactic total gastrectomy in E-cadherin (CDH1) mutations.

Seminars in oncology - 1 Apr 2022

Corso Giovanni, Magnoni Francesca, Nicastro Vincenzo, Bagnardi Vincenzo, Trovato Cristina Maria, Veronesi Paolo

Abstract excerpt

Individuals with germline E-cadherin (CDH1) mutations are at high risk of developing diffuse gastric cancer (GC) and prophylactic total gastrectomy (PTG) represents the only life-saving treatment. We reviewed all PTGs reported in literature associated with CDH1 germline mutations. A total of 224 PTGs were reported. The majority were described in the United States of America (50%), the Netherlands (17.8%), and...

Topics

Antigens, CD
Cadherins
Gastrectomy
Genetic Predisposition to Disease
Germ-Line Mutation
Humans
Stomach Neoplasms

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 35393124
DOI: 10.1053/j.seminoncol.2022.03.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-35393124-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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