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Article

E-cadherin mutations and hereditary gastric cancer: prevention by resection?

Digestive diseases (Basel, Switzerland) - 1 Jan 2002

Fitzgerald R C, Caldas C

Abstract excerpt

BACKGROUND: A small percentage of gastric cancers (1-3%) arise as a result of clearly identified inherited gastric cancer predisposition syndromes. Recently, linkage analysis has implicated E-cadherin (CDH1) mutations in a subset of dominantly inherited gastric cancers termed hereditary diffuse gastric cancer (HDGC). Heterozygotes with the CDH1 mutation have a 70-80% chance of developing gastric cancer and once...

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Source

Identifiers

PMID: 12145417
DOI: 10.1159/000063162

Genes

CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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