Article
CDH1 truncating mutations in the E-cadherin gene: an indication for total gastrectomy to treat hereditary diffuse gastric cancer.
Annals of surgery - 1 Jun 2007
Norton Jeffrey A, Ham Christine M, Van Dam Jacques, Jeffrey R Brooke, Longacre Teri A, Huntsman David G, Chun Nicki, Kurian Allison W, Ford James M
Abstract excerpt
BACKGROUND: Approximately 1% to 3% of all gastric cancers are associated with families exhibiting an autosomal dominant pattern of susceptibility. E-cadherin (CDH1) truncating mutations have been shown to be present in approximately 30% of families with hereditary diffuse gastric cancer (HDGC) and are associated with a significantly increased risk of gastric cancer and lobular breast cancer. METHODS: Individuals...
Topics
- Adenocarcinoma
- Anastomosis, Roux-en-Y
- Biopsy
- Breast Neoplasms
- Cadherins
- Carcinoma, Signet Ring Cell
- Diagnostic Imaging
- Female
- Gastrectomy
- Gastroscopy