Article
Frequent occurrence of p53 mutations in rhabdomyosarcoma and leiomyosarcoma, but not in fibrosarcoma and malignant neural tumors.
International journal of cancer - 22 Aug 1996
Würl P, Taubert H, Bache M, Kroll J, Meye A, Berger D, Siermann A, Holzhausen H J, Hinze R, Schmidt H, Rath F W
Abstract excerpt
We have analyzed soft-tissue sarcomas (STS) molecularly for mutations in the tumor-suppressor gene p53 and immunohisto-chemically for expression of p53 and mdm2 proteins. In this study, tumor samples from 3 groups of soft-tissue sarcomas, i.e., fibrosarcomas, myogenic sarcomas and malignant neura...
Topics
- Base Sequence
- Codon
- Fibrosarcoma
- Genes, p53
- Humans
- Leiomyosarcoma
- Molecular Sequence Data
- Mutation
- Neoplasms, Nerve Tissue
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Rhabdomyosarcoma