Article
Infrequent p53 gene mutations and lack of p53 protein expression in clear cell sarcoma of the kidney: immunohistochemical study and mutation analysis of p53 in renal tumors of unfavorable prognosis.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jun 2002
Hsueh Chuen, Wang Hao, Gonzalez-Crussi Frank, Lin Jer-Nan, Hung Iou-Jih, Yang Chao-Ping, Jiang Tang-Her
Abstract excerpt
A high prevalence of p53 gene mutation and protein expression has been found in the anaplastic variant of Wilms' tumor (WT), known to be associated with poor outcome. However, there are very few studies of p53 alterations in the other two rare and highly malignant renal tumors in childhood, in other words, clear cell sarcoma of the kidney (CCSK) and malignant rhabdoid tumor of the kidney (MRTK). Overexpression of...
Topics
- Adolescent
- Aged
- Base Sequence
- Child
- Child, Preschool
- DNA Mutational Analysis
- DNA, Neoplasm
- Female
- Humans
- Immunohistochemistry
- Infant
- Infant, Newborn
- Kidney Neoplasms