Article
Molecular and immunohistochemical identification of p53 alterations in bone and soft tissue sarcomas.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jan 1996
Mousses S, McAuley L, Bell R S, Kandel R, Andrulis I L
Abstract excerpt
p53 has been shown to suppress tumor growth by regulating the cell cycle and by triggering apoptosis. Acquired somatic mutations of the p53 gene have been observed in a variety of human malignancies, and these result in a loss of its tumor suppressor function. To examine the occurrence of p53 abnormalities in bone and soft tissue sarcomas, 113 tumors were subjected to molecular analysis and mutations were...
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