Mutation analysis of human cytokeratin 8 gene in malignant rhabdoid tumor: a possible association with intracytoplasmic inclusion body formation.

doi:10.1038/modpathol.3880506

Article

Mutation analysis of human cytokeratin 8 gene in malignant rhabdoid tumor: a possible association with intracytoplasmic inclusion body formation.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Feb 2002

Shiratsuchi Hideki, Saito Tsuyoshi, Sakamoto Akio, Itakura Eijun, Tamiya Sadafumi, Oshiro Yumi, Oda Yoshinao, Toh Satoshi, Komiyama Sohtaro, Tsuneyoshi Masazumi

Abstract excerpt

The rhabdoid cell, which is typically observed in malignant rhabdoid tumor (MRT) and other malignant neoplasms, has an eosinophilic cytoplasm containing a spheroid perinuclear inclusion body. This distinct cell is known to act as a highly aggressive indicator in many types of malignant tumors and is characterized by aggregates of intermediate filaments, comprising both vimentin and cytokeratin (CK) 8, which is...

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