Article
Development of rhabdomyosarcoma in HER-2/neu transgenic p53 mutant mice.
Cancer research - 1 Jun 2003
Nanni Patrizia, Nicoletti Giordano, De Giovanni Carla, Croci Stefania, Astolfi Annalisa, Landuzzi Lorena, Di Carlo Emma, Iezzi Manuela, Musiani Piero, Lollini Pier-Luigi
Abstract excerpt
Rhabdomyosarcomas derive from the skeletal muscle lineage and harbor a variety of genetic and molecular lesions. However, it is not clear which molecular alterations have a pathogenetic role. We show that activation of the HER-2/neu oncogene coupled with inactivation of the oncosuppressor gene p53 causes rhabdomyosarcoma in mice. At the age of 11-21 weeks, all male mice carrying both genetic lesions developed...
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