Article
Immunohistochemical detection of p53 in Wilms' tumors correlates with unfavorable outcome.
The American journal of pathology - 1 May 1996
Lahoti C, Thorner P, Malkin D, Yeger H
Abstract excerpt
The role of p53 in the pathogenesis and progression of Wilms' tumors is only partly understood. Although p53 mutations were initially reported only in anaplastic Wilms' tumors, we had reported that, of two of twenty-one cases that had a p53 mutation, one tumor showed no evidence of anaplasia. To...
Topics
- Blotting, Western
- Child
- Child, Preschool
- DNA, Neoplasm
- Female
- Gene Expression Regulation, Neoplastic
- Genes, Wilms Tumor
- Humans
- Immunohistochemistry
- Infant
- Kidney
- Kidney Neoplasms
- Male
- Mutation
- Polymorphism, Single-Stranded Conformational
- Prognosis
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53