Article
Polymorphism of the 5'-flanking region of the CYP2E1 gene: an association study with alcoholism.
Alcoholism, clinical and experimental research - 1 Jun 2001
Itoga S, Harada S, Nomura F
Abstract excerpt
BACKGROUND: Recently, a restriction fragment length polymorphism in the regulatory region of the CYP2E1 gene was identified. It has been suggested that the polymorphism is associated with the elevated activity of the cytochrome P-450 2E1 (CYP2E1) enzyme in obese or alcoholic subjects. However, significance of the polymorphism in connection with alcoholism has not been studied. In the present study, we have...
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