Article
Structural and functional characterization of the 5'-flanking region of the rat and human cytochrome P450 2E1 genes: identification of a polymorphic repeat in the human gene.
Biochemical and biophysical research communications - 24 Sept 1999
Hu Y, Hakkola J, Oscarson M, Ingelman-Sundberg M
Abstract excerpt
Cytochrome P450 2E1 (CYP2E1) is a toxicologically very important enzyme with a high extent of interindividual variability in expression. We sequenced and characterized the 5'-flanking region of the human and rat CYP2E1 genes. The identity between the human and rat sequences (-3.8 kb to +1 kb) was generally between 35 and 60%, and the most similar regions were found in the proximal part of the sequence. Two more...
Topics
- Alleles
- Animals
- Asian People
- Cloning, Molecular
- Cytochrome P-450 CYP2E1
- Enzyme Induction
- Gene Frequency
- Genes, Reporter
- Humans
- Liver Diseases, Alcoholic
- Neoplasms
- Polymorphism, Genetic
- Rats