Article
Alcohol-metabolizing enzyme polymorphisms and alcoholism in Japan.
Alcoholism, clinical and experimental research - 1 Aug 1995
Maezawa Y, Yamauchi M, Toda G, Suzuki H, Sakurai S
Abstract excerpt
The liver enzymes, alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), which are responsible for the oxidative metabolism of ethanol, are polymorphic in humans. Cytochrome P450IIE1, an ethanol-inducible isozyme of liver microsomal P450, is also important in ethanol metabolism. Genetic...
Topics
- Adult
- Aged
- Alcohol Dehydrogenase
- Alcoholism
- Aldehyde Dehydrogenase
- Cytochrome P-450 CYP2E1
- Cytochrome P-450 Enzyme System
- Ethanol
- Ethnicity
- Gene Frequency
- Genotype
- Humans
- Isoenzymes
- Japan
- Liver
- Male
- Middle Aged
- Oxidoreductases, N-Demethylating