Article
Tandem repeat polymorphism of the CYP2E1 gene: an association study with esophageal cancer and lung cancer.
Alcoholism, clinical and experimental research - 1 Aug 2002
Itoga Sakae, Nomura Fumio, Makino Yasuhiko, Tomonaga Takeshi, Shimada Hideaki, Ochiai Takenori, Iizasa Toshihiko, Baba Masayuki, Fujisawa Takehiko, Harada Shoji
Abstract excerpt
BACKGROUND: Cytochrome P-450 (CYP) enzymes have been shown to play important roles in chemical carcinogenesis. Reports have indicated that polymorphism in CYP1A1, CYP1A2, CYP2A6, CYP2E1, and CYP2D6 are associated with an altered risk of developing cancers of the lung, bladder, liver, and colon. CYP2E1 plays an important role in alcohol metabolism and participates in the metabolic activation of various...
Topics
- 5' Flanking Region
- Adult
- Aged
- Alcoholism
- Aldehyde Dehydrogenase
- Aldehyde Dehydrogenase, Mitochondrial
- Alleles
- Cytochrome P-450 CYP2E1
- Esophageal Neoplasms
- Exons
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype