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A polymorphism in the 5'-flanking region of the CYP2E1 gene and elevated lung adenocarcinoma risk in a Japanese population.

Oncology reports - 1 Oct 2005

Iizasa Toshihiko, Baba Masayuki, Saitoh Yukio, Suzuki Makoto, Haga Yukiko, Iyoda Akira, Chang Hao, Hiroshima Kenzo, Itoga Sakae, Tomonaga Takeshi, Nomura Fumio, Fujisawa Takehiko

Abstract excerpt

Cytochrome P450 2E1 (CYP2E1) catalyzes the metabolic activation of the procarcinogen, N-nitrosodimethylamine, and cytotoxic carbon tetrachloride compounds. A tandem repeat polymorphism in the 5'-flanking region of the CYP2E1 gene was investigated in non-small cell lung carcinoma (NSCLC) patients to clarify the relationship between CYP2E1 gene polymorphism and lung cancer susceptibility. Blood samples were taken...

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PMID: 16142352

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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