Article
Genetic polymorphisms of cytochrome P4502E1 related to the development of alcoholic liver disease.
Gastroenterology - 1 Nov 1994
Tsutsumi M, Takada A, Wang J S
Abstract excerpt
BACKGROUND/AIMS: Because heavy drinkers do not always develop alcoholic liver disease (ALD), genetic factors may be involved. Cytochrome P4502E1 is the main enzyme that oxidizes ethanol in the non-alcohol dehydrogenase pathway. Recently, the presence of genetic polymorphisms of this enzyme was co...
Topics
- Acetaminophen
- Adult
- Aged
- Alcohol Drinking
- Base Sequence
- Chi-Square Distribution
- Cytochrome P-450 CYP2E1
- Cytochrome P-450 Enzyme System
- Female
- Gene Frequency
- Genotype
- Heterozygote
- Homozygote
- Humans
- Liver Diseases, Alcoholic
- Male
- Middle Aged
- Molecular Sequence Data