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Article

Genetic polymorphisms of cytochrome P4502E1 related to the development of alcoholic liver disease.

Gastroenterology - 1 Nov 1994

Tsutsumi M, Takada A, Wang J S

Abstract excerpt

BACKGROUND/AIMS: Because heavy drinkers do not always develop alcoholic liver disease (ALD), genetic factors may be involved. Cytochrome P4502E1 is the main enzyme that oxidizes ethanol in the non-alcohol dehydrogenase pathway. Recently, the presence of genetic polymorphisms of this enzyme was confirmed. In the present study, the genotypes of P4502E1 were analyzed in patients with or without ALD. METHODS: After...

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PMID: 7926507
DOI: 10.1016/0016-5085(94)90546-0

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