Article
Single nucleotide polymorphisms and haplotypes of CYP1A2 in a Japanese population.
Drug metabolism and pharmacokinetics - 1 Feb 2005
Soyama Akiko, Saito Yoshiro, Hanioka Nobumitsu, Maekawa Keiko, Komamura Kazuo, Kamakura Shiro, Kitakaze Masafumi, Tomoike Hitonobu, Ueno Kazuyuki, Goto Yu-ichi, Kimura Hideo, Katoh Masaaki, Sugai Kenji, Saitoh Osamu, Kawai Mitsuru, Ohnuma Teiichi, Ohtsuki Taisuke, Suzuki Chieko, Minami Narihiro, Kamatani Naoyuki, Ozawa Shogo, Sawada Jun-ichi
Abstract excerpt
In order to identify genetic polymorphisms and haplotype frequencies of CYP1A2 in a Japanese population, the enhancer and promoter regions, all the exons with their surrounding introns, and intron 1 were sequenced from genomic DNA from 250 Japanese subjects. Thirty-three polymorphisms were found, including 13 novel ones: 2 in the enhancer region, 5 in the exons, and 6 in the introns. The most common single...
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