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Article

Transcriptional activity of the tandem repeat polymorphism in the 5'-flanking region of the human CYP2E1 gene.

Alcoholism, clinical and experimental research - 1 Aug 2003

Nomura Fumio, Itoga Sakae, Uchimoto Takayuki, Tomonaga Takeshi, Nezu Masahiko, Shimada Hideaki, Ochiai Takenori

Abstract excerpt

BACKGROUND: There are remarkable interindividual differences in the expression of cytochrome P-4502E1(CYP2E1), which in turn may alter susceptibility to alcohol-related diseases and various cancers. We recently characterized the tandem repeat polymorphism in the 5'-flanking region of the human CYP2E1 gene and found that subjects with the homozygous mutant-type (A4/A4) may be at higher risk of developing...

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PMID: 12960506
DOI: 10.1097/01.ALC.0000078612.01626.96

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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