Genetic polymorphisms in the 5'-flanking region change transcriptional regulation of the human cytochrome P450IIE1 gene.

doi:10.1093/oxfordjournals.jbchem.a123619

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Genetic polymorphisms in the 5'-flanking region change transcriptional regulation of the human cytochrome P450IIE1 gene.

Journal of biochemistry - 1 Oct 1991

Hayashi S, Watanabe J, Kawajiri K

Abstract excerpt

We identified genetic polymorphisms in the 5'-flanking region of the human cytochrome P450IIE1 gene and investigated the effect of these polymorphisms on the transcriptional regulation of the gene. PCR direct sequencing of the two homozygous alleles [types A (c1/c1) and C (c2/c2)] revealed the ex...

Topics

Amino Acid Sequence
Animals
Base Sequence
Binding Sites
Chloramphenicol O-Acetyltransferase
Cytochrome P-450 CYP2E1
Cytochrome P-450 Enzyme System
DNA
DNA-Binding Proteins
Deoxyribonuclease I
Gene Expression Regulation, Enzymologic
Genotype
Hepatocyte Nuclear Factor 1
Hepatocyte Nuclear Factor 1-alpha
Hepatocyte Nuclear Factor 1-beta
Humans
Molecular Sequence Data
Nuclear Proteins

Source

Open in PubMed

Identifiers

PMID: 1778977
DOI: 10.1093/oxfordjournals.jbchem.a123619

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1778977-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics