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Article

The selectivity filter of the voltage-gated sodium channel is involved in channel activation.

The Journal of biological chemistry - 27 Jul 2001

Hilber K, Sandtner W, Kudlacek O, Glaaser I W, Weisz E, Kyle J W, French R J, Fozzard H A, Dudley S C, Todt H

Abstract excerpt

Amino acids located in the outer vestibule of the voltage-gated Na+ channel determine the permeation properties of the channel. Recently, residues lining the outer pore have also been implicated in channel gating. The domain (D) IV P-loop residue alanine 1529 forms a part of the putative selectivity filter of the adult rat skeletal muscle (mu1) Na+ channel. Here we report that replacement of alanine 1529 by...

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Identifiers

PMID: 11382756
DOI: 10.1074/jbc.M101933200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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