Article
A negatively charged residue in the outer mouth of rat sodium channel determines the gating kinetics of the channel.
American journal of physiology. Cell physiology - 1 May 2003
Zhang Zhao, Xu Yanfang, Dong Pei Hong, Sharma Dipika, Chiamvimonvat Nipavan
Abstract excerpt
Previous studies using combined techniques of site-directed mutagenesis and electrophysiology of voltage-gated Na(+) channels have demonstrated that there are significant overlaps in the regions that are important for the two fundamental properties of the channels, namely gating and permeation. We have previously shown that a pore-lining residue, W402 in S5-S6 region (P loop) in domain I of the micro1 skeletal...
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