Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A naturally occurring amino acid substitution in the voltage-dependent sodium channel selectivity filter affects channel gating.

Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology - 1 Oct 2013

Wu Mingming, Ye Na, Sengupta Biswa, Zakon Harold H

Abstract excerpt

The pore of sodium channels contains a selectivity filter made of 4 amino acids, D/E/K/A. In voltage sensitive sodium channel (Nav) channels from jellyfish to human the fourth amino acid is Ala. This Ala, when mutated to Asp, promotes slow inactivation. In some Nav channels of pufferfishes, the A...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fish Proteins
Share to Insect Proteins
Share to Ion Channel Gating

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Membrane Potentials

Share to Muscle Proteins

Share to Sodium

Share to Sodium Channels

Share to Xenopus

Source

Identifiers

PMID: 23979192
DOI: 10.1007/s00359-013-0845-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23979192-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A naturally occurring amino acid substitution in the voltage-dependent sodium channel selectivity filter affects channel gating.PMID 23979192Read ↗

The selectivity filter of the voltage-gated sodium channel is involved in channel activation.Semantic proximity Read ↗

Molecular bases for the asynchronous activation of sodium and potassium channels required for nerve impulse generation.Semantic proximity Read ↗

Voltage-gated sodium channels: action players with many faces.Semantic proximity Read ↗

Characterization of specific allosteric effects of the Na+ channel β1 subunit on the Nav1.4 isoform.Semantic proximity Read ↗

CaV3.1 channel pore pseudo-symmetry revealed by selectivity filter mutations in its domains I/II.Semantic proximity Read ↗

Voltage-gated Sodium Channels and Blockers: An Overview and Where Will They Go?Semantic proximity Read ↗

Structure-based assessment of disease-related mutations in human voltage-gated sodium channels.Semantic proximity Read ↗

Sodium channel inactivation is altered by substitution of voltage sensor positive charges.Semantic proximity Read ↗

Comparative structural analysis of human Nav1.1 and Nav1.5 reveals mutational hotspots for sodium channelopathies.Semantic proximity Read ↗

Role in fast inactivation of conserved amino acids in the IV/S4-S5 loop of the human muscle Na+ channel.Semantic proximity Read ↗

Ionic selectivity and thermal adaptations within the voltage-gated sodium channel family of alkaliphilic Bacillus.Semantic proximity Read ↗

A naturally occurring omega current in a Kv3 family potassium channel from a platyhelminth.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.