Article
Molecular determinants of voltage-dependent slow inactivation of the Ca2+ channel.
The Journal of biological chemistry - 1 Mar 2002
Shi Chengzhang, Soldatov Nikolai M
Abstract excerpt
Ba(2+) current through the L-type Ca(2+) channel inactivates essentially by voltage-dependent mechanisms with fast and slow kinetics. Here we found that slow inactivation is mediated by an annular determinant composed of hydrophobic amino acids located near the cytoplasmic ends of transmembrane segments S6 of each repeat of the alpha(1C) subunit. We have determined the molecular requirements that completely...
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