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Article

Characterization of specific allosteric effects of the Na+ channel β1 subunit on the Nav1.4 isoform.

European biophysics journal : EBJ - 1 Jul 2017

Sánchez-Solano Alfredo, Islas Angel A, Scior Thomas, Paiz-Candia Bertin, Millan-PerezPeña Lourdes, Salinas-Stefanon Eduardo M

Abstract excerpt

The mechanism of inactivation of mammalian voltage-gated Na+ channels involves transient interactions between intracellular domains resulting in direct pore occlusion by the IFM motif and concomitant extracellular interactions with the β1 subunit. Navβ1 subunits constitute single-pass transmembrane proteins that form protein-protein associations with pore-forming α subunits to allosterically modulate the Na+...

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PMID: 28012039
DOI: 10.1007/s00249-016-1193-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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