Article
A single residue differentiates between human cardiac and skeletal muscle Na+ channel slow inactivation.
Biophysical journal - 1 May 2001
Vilin Y Y, Fujimoto E, Ruben P C
Abstract excerpt
Slow inactivation determines the availability of voltage-gated sodium channels during prolonged depolarization. Slow inactivation in hNa(V)1.4 channels occurs with a higher probability than hNa(V)1.5 sodium channels; however, the precise molecular mechanism for this difference remains unclear. Using the macropatch technique we show that the DII S5-S6 p-region uniquely confers the probability of slow inactivation...
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