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Article

Comparison of slow inactivation in human heart and rat skeletal muscle Na+ channel chimaeras.

The Journal of physiology - 15 Feb 1999

O'Reilly J P, Wang S Y, Kallen R G, Wang G K

Abstract excerpt

1. Voltage-gated Na+ channels undergo two types of inactivation in response to depolarization. One type, fast inactivation, occurs with a time scale of milliseconds. The other, slow inactivation, occurs over seconds to minutes. In addition, these two processes appear to be distinct at the molecular level. However, the molecular mechanism of Na+ channel slow inactivation is unknown. 2. We used patch clamp...

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Identifiers

PMID: 9925878
DOI: 10.1111/j.1469-7793.1999.061ad.x
PMCID: PMC2269135

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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