Article
Comparison of slow inactivation in human heart and rat skeletal muscle Na+ channel chimaeras.
The Journal of physiology - 15 Feb 1999
O'Reilly J P, Wang S Y, Kallen R G, Wang G K
Abstract excerpt
1. Voltage-gated Na+ channels undergo two types of inactivation in response to depolarization. One type, fast inactivation, occurs with a time scale of milliseconds. The other, slow inactivation, occurs over seconds to minutes. In addition, these two processes appear to be distinct at the molecul...
Topics
- Algorithms
- Animals
- Cell Line
- Electrophysiology
- Humans
- Ion Channel Gating
- Kidney
- Membrane Potentials
- Muscle, Skeletal
- Myocardium
- Patch-Clamp Techniques
- Phenotype
- Rats
- Recombinant Fusion Proteins
- Sodium Channels
- Transfection