Article
A molecular switch between the outer and the inner vestibules of the voltage-gated Na+ channel.
The Journal of biological chemistry - 10 Dec 2010
Zarrabi Touran, Cervenka Rene, Sandtner Walter, Lukacs Peter, Koenig Xaver, Hilber Karlheinz, Mille Markus, Lipkind Gregory M, Fozzard Harry A, Todt Hannes
Abstract excerpt
Voltage-gated ion channels are transmembrane proteins that undergo complex conformational changes during their gating transitions. Both functional and structural data from K(+) channels suggest that extracellular and intracellular parts of the pore communicate with each other via a trajectory of interacting amino acids. No crystal structures are available for voltage-gated Na(+) channels, but functional data...
Topics
- Animals
- Cysteine
- Electrophysiology
- Female
- Ion Channel Gating
- Isoleucine
- Kinetics
- Muscle Proteins
- Muscle, Skeletal
- Mutation
- Potassium Channels