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Article

A molecular switch between the outer and the inner vestibules of the voltage-gated Na+ channel.

The Journal of biological chemistry - 10 Dec 2010

Zarrabi Touran, Cervenka Rene, Sandtner Walter, Lukacs Peter, Koenig Xaver, Hilber Karlheinz, Mille Markus, Lipkind Gregory M, Fozzard Harry A, Todt Hannes

Abstract excerpt

Voltage-gated ion channels are transmembrane proteins that undergo complex conformational changes during their gating transitions. Both functional and structural data from K(+) channels suggest that extracellular and intracellular parts of the pore communicate with each other via a trajectory of interacting amino acids. No crystal structures are available for voltage-gated Na(+) channels, but functional data...

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Identifiers

PMID: 20926383
DOI: 10.1074/jbc.M110.132886
PMCID: PMC2998134

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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