A gating charge interaction required for late slow inactivation of the bacterial sodium channel NavAb.

Abstract excerpt

Voltage-gated sodium channels undergo slow inactivation during repetitive depolarizations, which controls the frequency and duration of bursts of action potentials and prevents excitotoxic cell death. Although homotetrameric bacterial sodium channels lack the intracellular linker-connecting homologous domains III and IV that causes fast inactivation of eukaryotic sodium channels, they retain the molecular...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Action Potentials
• Share to Bacterial Proteins