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Article

Caenorhabditis elegans EAK-3 inhibits dauer arrest via nonautonomous regulation of nuclear DAF-16/FoxO activity.

Developmental biology - 15 Mar 2008

Zhang Yanmei, Xu Jinling, Puscau Cristina, Kim Yongsoon, Wang Xi, Alam Hena, Hu Patrick J

Abstract excerpt

Insulin regulates development, metabolism, and lifespan via a conserved PI3K/Akt pathway that promotes cytoplasmic sequestration of FoxO transcription factors. The regulation of nuclear FoxO is poorly understood. In the nematode Caenorhabditis elegans, insulin-like signaling functions in larvae to inhibit dauer arrest and acts during adulthood to regulate lifespan. In a screen for genes that modulate C. elegans...

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Identifiers

PMID: 18241854
DOI: 10.1016/j.ydbio.2007.12.032
PMCID: PMC2350227

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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