Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor.

doi:10.1101/gad.12.16.2488

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Article

Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor.

Genes & development - 15 Aug 1998

Paradis S, Ruvkun G

Abstract excerpt

A neurosecretory pathway regulates a reversible developmental arrest and metabolic shift at the Caenorhabditis elegans dauer larval stage. Defects in an insulin-like signaling pathway cause arrest at the dauer stage. We show here that two C. elegans Akt/PKB homologs, akt-1 and akt-2, transduce in...

Topics

Amino Acid Sequence
Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Forkhead Transcription Factors
Gene Expression Regulation, Enzymologic
Helminth Proteins
Life Expectancy
Molecular Sequence Data
Mutation
Oncogene Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphatidylinositol 3-Kinases

Protein Serine-Threonine Kinases

Proto-Oncogene Proteins

Proto-Oncogene Proteins c-akt

Receptor, Insulin

Sequence Homology, Amino Acid

Signal Transduction

Source

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Identifiers

PMID: 9716402
DOI: 10.1101/gad.12.16.2488
PMCID: PMC317081

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9716402-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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