Article
A transcriptional activation function of p53 is dispensable for and inhibitory of its apoptotic function.
Oncogene - 8 Feb 2001
Kokontis J M, Wagner A J, O'Leary M, Liao S, Hay N
Abstract excerpt
The tumor suppressor p53 is an inducer of cell cycle arrest and programmed cell death (apoptosis). The ability of p53 to induce cell cycle arrest is linked to its ability to induce transcription of genes such as the cyclin-dependent kinase inhibitor p21. However, the dependence of p53-mediated apoptosis on transcriptional activation remains controversial. Ectopic expression of a temperature-sensitive (ts) p53...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.