The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality.

Abstract excerpt

The role of transcriptional activation in p53 function is highly controversial. To define this role in vivo, we generated a Trp53 knock-in construct encoding a protein carrying mutations of two residues that are crucial for transactivation (L25Q,W26S). Here we show that these mutations have selective effects on the biological functions of p53. Although its ability to activate various p53 target genes is largely...

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