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Article

Induction of apoptosis in HeLa cells by trans-activation-deficient p53.

Genes & development - 1 Sept 1995

Haupt Y, Rowan S, Shaulian E, Vousden K H, Oren M

Abstract excerpt

The p53 tumor suppressor protein is a transcriptional activator, which can mediate apoptotic cell death in a variety of cell types. To determine whether sequence-specific trans-activation is a prerequisite for the induction of apoptosis by p53, the apoptotic effects of various p53 deletion mutants were monitored in an assay based on the transient transfection of HeLa cells. A truncated protein (p53dl214),...

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Identifiers

PMID: 7657168
DOI: 10.1101/gad.9.17.2170

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Induction of apoptosis in HeLa cells by trans-activation-deficient p53.PMID 7657168Read ↗

A transcriptional activation function of p53 is dispensable for and inhibitory of its apoptotic function.Semantic proximity Read ↗

Definition of a p53 transactivation function-deficient mutant and characterization of two independent p53 transactivation subdomains.Semantic proximity Read ↗

The polyproline region of p53 is required to activate apoptosis but not growth arrest.Semantic proximity Read ↗

A function in apoptosis other than transactivation inherent in the NH2-terminal domain of p53.Semantic proximity Read ↗

p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells.Semantic proximity Read ↗

Selective induction of apoptosis through the FADD/caspase-8 pathway by a p53 c-terminal peptide in human pre-malignant and malignant cells.Semantic proximity Read ↗

Lack of correlation between p53-dependent transcriptional activity and the ability to induce apoptosis among 179 mutant p53s.Semantic proximity Read ↗

The apoptotic and transcriptional transactivation activities of p53 can be dissociated.Semantic proximity Read ↗

A single mutant, A276S of p53, turns the switch to apoptosis.Semantic proximity Read ↗

p53 transactivation domain mutant Q22, S23 is impaired for repression of promoters and mediation of apoptosis.Semantic proximity Read ↗

Restoration of p53 expression sensitizes human papillomavirus type 16 immortalized human keratinocytes to CD95-mediated apoptosisSemantic proximity Read ↗

Identification of a novel p53 functional domain that is necessary for efficient growth suppressionSemantic proximity Read ↗

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