Induction of apoptosis in HeLa cells by trans-activation-deficient p53.

doi:10.1101/gad.9.17.2170

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Article

Induction of apoptosis in HeLa cells by trans-activation-deficient p53.

Genes & development - 1 Sept 1995

Haupt Y, Rowan S, Shaulian E, Vousden K H, Oren M

Abstract excerpt

The p53 tumor suppressor protein is a transcriptional activator, which can mediate apoptotic cell death in a variety of cell types. To determine whether sequence-specific trans-activation is a prerequisite for the induction of apoptosis by p53, the apoptotic effects of various p53 deletion mutant...

Topics

Animals
Apoptosis
Cell Transformation, Neoplastic
Cells, Cultured
DNA
HeLa Cells
Humans
Mutation
Oncogenes
Rats
Receptors, Interleukin-2
Sequence Deletion
Transcriptional Activation
Transfection
Tumor Suppressor Protein p53

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