Article
The apoptotic and transcriptional transactivation activities of p53 can be dissociated.
Biochemistry and cell biology = Biochimie et biologie cellulaire - 1 Jan 1997
Bissonnette N, Wasylyk B, Hunting D J
Abstract excerpt
Previous studies have shown that the apoptotic response of cells following DNA damage requires p53 expression. Wild-type p53 protein levels increase in response to DNA damage and its growth-suppressive action is thought to be mediated by transcriptional activation of the p21/WAF1/CIP1 gene, the p...
Topics
- Animals
- Apoptosis
- Cell Line, Transformed
- Culture Media, Serum-Free
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- DNA Damage
- Fibroblasts
- Gamma Rays
- Humans
- Hydrolysis
- Mice
- Mice, Inbred BALB C
- Mice, Knockout
- Mutation
- Peptide Hydrolases
- Poly(ADP-ribose) Polymerases
- RNA Polymerase II