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Article

Definition of a p53 transactivation function-deficient mutant and characterization of two independent p53 transactivation subdomains.

Oncogene - 8 Apr 1999

Venot C, Maratrat M, Sierra V, Conseiller E, Debussche L

Abstract excerpt

The wild-type protein product of the p53 tumor suppressor gene can activate transcription of genes which are involved in mediating either growth arrest, e.g. WAF1 or apoptotis, e.g. BAX and PICG3. Additionally, p53 can repress a variety of promoters, which, in turn, may be responsible for the functional activities exhibited by p53. This study shows that the Q22, S23 double mutation, which is known to inactivate a...

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Source

Identifiers

PMID: 10327062
DOI: 10.1038/sj.onc.1202539

Genes

BAX

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Definition of a p53 transactivation function-deficient mutant and characterization of two independent p53 transactivation subdomains.PMID 10327062Read ↗

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