Article
p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells.
Genes & development - 1 Oct 1996
Chen X, Ko L J, Jayaraman L, Prives C
Abstract excerpt
It is well established that induction of the p53 tumor suppressor protein in cells can lead to either cell cycle arrest or apoptosis. To further understand features of p53 that contribute to these cell responses several p53-null Saos2 and H1299 cell lines were generated that express wild-type or...
Topics
- Apoptosis
- Camptothecin
- Carcinoma, Small Cell
- Cell Cycle
- Cell Division
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- DNA Damage
- Enzyme Inhibitors
- Humans
- Mutation
- Osteosarcoma
- Tetracycline
- Topoisomerase I Inhibitors
- Transcription, Genetic
- Transcriptional Activation
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53