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Pro- and anti-apoptotic effects of p53 in cisplatin-treated human testicular cancer are cell context-dependent

11 Dec 2012

Abstract excerpt

In murine testicular cancer (TC) cells wild-type p53 contributes to sensitivity to DNA-damaging drugs in a dose-dependent way. In human TC, however, the role of wild-type p53 functionality in chemotherapeutic response remains elusive. We analyzed functionality of wild-type p53 in cisplatin sensitivity in the human TC setting using a p53 short interfering (si)RNA approach. The cisplatin-sensitive TC cell line...

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PMID: 23165211
DOI: 10.4161/cc.22803

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