Article
How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?
Cell death and differentiation - 1 Jan 2018
Aubrey Brandon J, Kelly Gemma L, Janic Ana, Herold Marco J, Strasser Andreas
Abstract excerpt
The tumour suppressor gene TP53 is mutated in ~50% of human cancers. In addition to its function in tumour suppression, p53 also plays a major role in the response of malignant as well as nontransformed cells to many anticancer therapeutics, particularly those that cause DNA damage. P53 forms a homotetrameric transcription factor that is reported to directly regulate ~500 target genes, thereby controlling a broad...
Topics
- Animals
- Apoptosis
- Humans
- Mice
- Mutation
- Neoplasms
- Proto-Oncogene Proteins c-bcl-2
- Signal Transduction
- Transcription Factors
- Tumor Suppressor Protein p53