Article
The polyproline region of p53 is required to activate apoptosis but not growth arrest.
Oncogene - 18 Aug 1997
Sakamuro D, Sabbatini P, White E, Prendergast G C
Abstract excerpt
p53 is a pivotal regulator of apoptosis but its mechanism of action is obscure. We report that the polyproline (PP) region located between p53's transactivation and DNA binding domains is necessary to induce apoptosis but not cell growth arrest. The PP region was dispensable for DNA binding, inhibition of SAOS-2 tumor cell growth, suppression of E1A + RAS cell transformation, and cell cycle inhibition. A...
Topics
- Amino Acid Sequence
- Animals
- Apoptosis
- Cell Division
- Cell Line
- Cell Transformation, Viral
- Molecular Sequence Data
- Mutation
- Peptides
- Rats
- Sequence Alignment
- Transcriptional Activation