Article
Microsatellite instability in transforming growth factor-beta 1 type II receptor gene in alveolar lining epithelial cells of idiopathic pulmonary fibrosis.
American journal of respiratory cell and molecular biology - 1 Apr 2001
Mori M, Kida H, Morishita H, Goya S, Matsuoka H, Arai T, Osaki T, Tachibana I, Yamamoto S, Sakatani M, Ito M, Ogura T, Hayashi S
Abstract excerpt
It has been reported that transforming growth factor (TGF)-beta, which plays an integral role in the pathogenesis of idiopathic pulmonary fibrosis (IPF), suppresses proliferation of alveolar epithelial cells in vitro. Although hyperplastic lesions of alveolar lining epithelial cells (ALECs) are characteristic pathologic features of IPF, the mechanism of their involvement in the pathogenesis has not yet been...
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