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Article

Frequent Genetic Alterations at the Microsatellite Level in Cytologic Sputum Samples of Patients with Idiopathic Pulmonary Fibrosis

1 Sept 2000

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) is a disease of unknown etiology associated with DNA damage and malignancy. Bronchogenic carcinoma is the cause of death in 10% to 13% of IPF patients. Microsatellite instability (MSI) and loss of heterozygosity (LOH) are frequently detected in cancers. If these genetic alterations could be observed in IPF, they might explain the higher relative risk of lung cancer in this...

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PMID: 10988139
DOI: 10.1164/ajrccm.162.3.9911119

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