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Article

Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability.

Science (New York, N.Y.) - 2 Jun 1995

Markowitz S, Wang J, Myeroff L, Parsons R, Sun L, Lutterbaugh J, Fan R S, Zborowska E, Kinzler K W, Vogelstein B, Brattain M, Willson J K V

Abstract excerpt

Transforming growth factor-beta (TGF-beta) is a potent inhibitor of epithelial cell growth. Human colon cancer cell lines with high rates of microsatellite instability were found to harbor mutations in the type II TGF-beta receptor (RII) gene. Eight such examples, due to three different mutations, were identified. The mutations were clustered within small repeated sequences in the RII gene, were accompanied by...

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Identifiers

PMID: 7761852
DOI: 10.1126/science.7761852

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability.PMID 7761852Read ↗

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Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers.Semantic proximity Read ↗

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The somatic mutation frequency of the transforming growth factor beta receptor type II gene varies widely among different cancers with microsatellite instability.Semantic proximity Read ↗

Tumor suppressor activity of the TGF-beta pathway in human cancers.Semantic proximity Read ↗

Transfection of the type II TGF-beta receptor into colon cancer cells increases receptor expression, inhibits cell growth, and reduces the malignant phenotype.Semantic proximity Read ↗

Mutational inactivation of <i>TGFBR2</i> in microsatellite unstable colon cancer arises from the cooperation of genomic instability and the clonal outgrowth of transforming growth factor β resistant cellsSemantic proximity Read ↗

Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer.Semantic proximity Read ↗

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