Article
Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability.
Science (New York, N.Y.) - 2 Jun 1995
Markowitz S, Wang J, Myeroff L, Parsons R, Sun L, Lutterbaugh J, Fan R S, Zborowska E, Kinzler K W, Vogelstein B
Abstract excerpt
Transforming growth factor-beta (TGF-beta) is a potent inhibitor of epithelial cell growth. Human colon cancer cell lines with high rates of microsatellite instability were found to harbor mutations in the type II TGF-beta receptor (RII) gene. Eight such examples, due to three different mutations, were identified. The mutations were clustered within small repeated sequences in the RII gene, were accompanied by...
Topics
- Amino Acid Sequence
- Animals
- Colonic Neoplasms
- Colorectal Neoplasms, Hereditary Nonpolyposis
- DNA Repair
- DNA, Neoplasm
- DNA, Satellite
- Disease Progression
- Frameshift Mutation
- Humans