Article
Diminished expression of the type II receptor for TGFbeta (TGFbetaRII) in T lymphocytes from patients with Sezary syndrome is not due to mutations in the receptor's poly-A tract: limitations of the standard RT-PCR in cDNA sequence analysis of homopolymeric base stretches.
Archivum immunologiae et therapiae experimentalis - 1 Jan 2002
Zhang Qian, Capocasale Renold J, Fox Floyd E, Bedian Vahe, Vonderheid Eric C, Rook Alain, Moore Jonni S, Nowell Peter C, Haines Dale S, Wasik Mariusz A
Abstract excerpt
Peripheral blood lymphocytes from patients with Sezary syndrome (SzS) frequently demonstrate decreased surface expression of transforming growth factor beta receptor II (TGFbetaRII). The mechanism of this low TGFbetaRII expression remains unknown. Because mutations within the poly-A tract of the TGFbetaRII sequence (nucleotides 709-718) were shown to result in diminished TGFbetaRII expression in other types of...
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