Article
Mutation of the transforming growth factor-beta type II receptor gene is a rare event in human sporadic gastric carcinomas.
International journal of oncology - 1 May 1998
Shitara Y, Yokozaki H, Yasui W, Takenoshita S, Nagamachi Y, Tahara E
Abstract excerpt
Mutations of the transforming growth factor-beta type II receptor (TGF-beta RII) gene have been detected in several human cancers. However, mutation analysis of coding sequences of TGF-beta RII in gastric carcinomas has not yet been fully elucidated. We performed PCR-SSCP analysis and direct DNA...
Topics
- DNA Primers
- Exons
- Frameshift Mutation
- Genetic Variation
- Humans
- Introns
- Point Mutation
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Polymorphism, Single-Stranded Conformational
- Protein Serine-Threonine Kinases
- Receptor, Transforming Growth Factor-beta Type II
- Receptors, Transforming Growth Factor beta
- Stomach Neoplasms
- Tumor Cells, Cultured