Article
Infrequent mutations of the transforming growth factor beta-type II receptor gene at chromosome 3p22 in human lung cancers with chromosome 3p deletions.
Carcinogenesis - 1 May 1997
Tani M, Takenoshita S, Kohno T, Hagiwara K, Nagamachi Y, Harris C C, Yokota J
Abstract excerpt
Mutations in the transforming growth factor beta-type II receptor (TGFbeta RII) gene have been detected in several types of human cancers that represent the phenotype of genomic instability. The TGFbeta RII gene has been mapped to chromosome 3p, on which loss of heterozygosity (LOH) was frequentl...
Topics
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Small Cell
- Chromosome Deletion
- Chromosome Mapping
- Chromosomes, Human, Pair 3
- Humans
- Lung Neoplasms
- Mutation
- Polymorphism, Single-Stranded Conformational
- Protein Serine-Threonine Kinases
- Receptor, Transforming Growth Factor-beta Type II
- Receptors, Transforming Growth Factor beta