Article
Absence of mutatins in the analysis of coding sequences of the entire transforming growth factor beta type II receptor gene in sporadic humangastric cancer using genomic DNA and intron primers.
Oncology reports - 1 Jan 2000
Takenoshita S, Mogi A, Osawa H, Sunaga H, Kakegawa H, Tani M, Morinaga N, Kato R, Hagiwara K, Nagamachi Y
Abstract excerpt
Mutations in the transforming growth factor beta type II receptor (TGFbetaRII) gene have been detected in several human cancers that represent the phenotype of genomic instability. To establish a basis for diagnosis of cancer patients, we previously determined the exon-intron organization of the TGFbetaRII gene. The results indicated that TGFbetaRII protein is encoded by 567 codons in 7 exons. In this study, we...
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