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Article

Mutation analysis of the transforming growth factor-beta type II receptor in human cell lines resistant to growth inhibition by transforming growth factor-beta.

Oncogene - 3 Jul 1997

Vincent F, Nagashima M, Takenoshita S, Khan M A, Gemma A, Hagiwara K, Bennett W P

Abstract excerpt

The transforming growth factor-beta (TGF-beta) binds the type II TGF-beta growth factor receptor (RII) to inhibit the growth of most epithelial tissues. Most human colon and gastric cancers with microsatellite instability (MI) have frameshift mutations in polynucleotide repeats within the RII cod...

Topics

Cell Division
Colonic Neoplasms
DNA Mutational Analysis
Humans
Microsatellite Repeats
Mutation
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational
Protein Serine-Threonine Kinases
Receptor, Transforming Growth Factor-beta Type II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Transforming Growth Factor beta

Stomach Neoplasms

Transforming Growth Factor beta

Tumor Cells, Cultured

Source

Identifiers

PMID: 9233784
DOI: 10.1038/sj.onc.1201166

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9233784-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Mutation analysis of the transforming growth factor-beta type II receptor in human cell lines resistant to growth inhibition by transforming growth factor-beta.PMID 9233784Read ↗

Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability.Semantic proximity Read ↗

Absence of mutations in the analysis of coding sequences of the entire transforming growth factor-beta type II receptor gene in sporadic human breast cancers.Semantic proximity Read ↗

The somatic mutation frequency of the transforming growth factor beta receptor type II gene varies widely among different cancers with microsatellite instability.Semantic proximity Read ↗

Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers.Semantic proximity Read ↗

Tumor suppressor activity of the TGF-beta pathway in human cancers.Semantic proximity Read ↗

Transfection of the type II TGF-beta receptor into colon cancer cells increases receptor expression, inhibits cell growth, and reduces the malignant phenotype.Semantic proximity Read ↗

Mutation of the type II transforming growth factor-beta receptor is coincident with the transformation of human colon adenomas to malignant carcinomas.Semantic proximity Read ↗

Mutations of transforming growth factor beta 1 type II receptor, BAX, and insulin-like growth factor II receptor genes in microsatellite unstable cell lines.Semantic proximity Read ↗

Development of TGF-beta resistance during malignant progression.Semantic proximity Read ↗

Mutation of the transforming growth factor-beta type II receptor gene is a rare event in human sporadic gastric carcinomas.Semantic proximity Read ↗

Mutational analysis of the transforming growth factor beta receptor type II gene in hereditary nonpolyposis colorectal cancer and early-onset colorectal cancer patients.Semantic proximity Read ↗

Mutational inactivation of <i>TGFBR2</i> in microsatellite unstable colon cancer arises from the cooperation of genomic instability and the clonal outgrowth of transforming growth factor β resistant cellsSemantic proximity Read ↗

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