Article
The somatic mutation frequency of the transforming growth factor beta receptor type II gene varies widely among different cancers with microsatellite instability.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology - 1 Oct 1996
Abe T, Ouyang H, Migita T, Kato Y, Kimura M, Shiiba K, Sunamura M, Matsuno S, Horii A
Abstract excerpt
Disruption of the DNA mismatch repair system, characterized by microsatellite instability (MSI), plays an important role in the course of human carcinogenesis. Frequent somatic mutations in a polyadenine (poly(A)) tract and two GT repeats within the coding region of the transforming growth factor...
Topics
- Adult
- Aged
- Chromosome Deletion
- Colorectal Neoplasms
- Endometrial Neoplasms
- Female
- Humans
- Lung Neoplasms
- Microsatellite Repeats
- Middle Aged
- Mutation
- Neoplasms
- Pancreatic Neoplasms
- Receptors, Transforming Growth Factor beta