Article
Genomic instability in the type II TGF-beta1 receptor gene in atherosclerotic and restenotic vascular cells.
The Journal of clinical investigation - 1 Nov 1997
McCaffrey T A, Du B, Consigli S, Szabo P, Bray P J, Hartner L, Weksler B B, Sanborn T A, Bergman G, Bush H L
Abstract excerpt
Cells proliferating from human atherosclerotic lesions are resistant to the antiproliferative effect of TGF-beta1, a key factor in wound repair. DNA from human atherosclerotic and restenotic lesions was used to test the hypothesis that microsatellite instability leads to specific loss of the Type II receptor for TGF-beta1 (TbetaR-II), causing acquired resistance to TGF-beta1. High fidelity PCR and restriction...
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