Article
The insulin-like growth factor II receptor gene is mutated in genetically unstable cancers of the endometrium, stomach, and colorectum.
Cancer research - 15 May 1997
Ouyang H, Shiwaku H O, Hagiwara H, Miura K, Abe T, Kato Y, Ohtani H, Shiiba K, Souza R F, Meltzer S J, Horii A
Abstract excerpt
Disruption of the DNA mismatch repair system, characterized by microsatellite instability (MI), plays an important role in the course of human carcinogenesis. Repetitive sequences constitute targets for mutation in MI+ cells, and frequent mutations have indeed been reported in such regions within the transforming growth factor beta receptor II (RII) gene in genetically unstable colorectal and gastric cancers....
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