Article
The insulin-like growth factor II receptor gene is mutated in genetically unstable cancers of the endometrium, stomach, and colorectum.
Cancer research - 15 May 1997
Ouyang H, Shiwaku H O, Hagiwara H, Miura K, Abe T, Kato Y, Ohtani H, Shiiba K, Souza R F, Meltzer S J, Horii A
Abstract excerpt
Disruption of the DNA mismatch repair system, characterized by microsatellite instability (MI), plays an important role in the course of human carcinogenesis. Repetitive sequences constitute targets for mutation in MI+ cells, and frequent mutations have indeed been reported in such regions within...
Topics
- Breast Neoplasms
- Colorectal Neoplasms
- DNA Mutational Analysis
- DNA, Neoplasm
- Endometrial Neoplasms
- Female
- Histones
- Humans
- Mutation
- Neoplasms
- Ovarian Neoplasms
- Pancreatic Neoplasms
- Polymerase Chain Reaction
- Receptor, IGF Type 2
- Repetitive Sequences, Nucleic Acid