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Article

Closely related proteins MBD2 and MBD3 play distinctive but interacting roles in mouse development.

Genes & development - 15 Mar 2001

Hendrich B, Guy J, Ramsahoye B, Wilson V A, Bird A

Abstract excerpt

MBD2 and MBD3 are closely related proteins with consensus methyl-CpG binding domains. MBD2 is a transcriptional repressor that specifically binds to methylated DNA and is a component of the MeCP1 protein complex. In contrast, MBD3 fails to bind methylated DNA in murine cells, and is a component of the Mi-2/NuRD corepressor complex. We show by gene targeting that the two proteins are not functionally redundant in...

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Source

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Identifiers

PMID: 11274056
DOI: 10.1101/gad.194101
PMCID: PMC312657

Genes

MBD2
MBD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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